Garden Route
Regardless of whether you are a nature lover or history enthusiast, for sheer variety there is probably very little which beats a trip from Cape Town to Durban via the famous Garden Route. The scenery is amazing and there are ample opportunities to enjoy splendid beaches along the way (such as at Jeffrey's Bay, which is a renowned site for surfers) and also to take in natural indigenous forests. Indeed, one of the highlights of any such trip must be the Tsitsikamma and Storm's River region of the Eastern Cape. Adventurous travellers are sure to enjoy doing the Tsitsikamma Canopy Tour or, for the brave, there is the Bloukrans Bridge Bungy Jump which is listed by Guinness World Records as "the highest commercially operated Bungy Jump in the world". For the more laid-back traveller a visit to the Addo Elephant National Park is very highly recommended, as is a visit to the Cango Wildlife Ranch and, of course, the Cango Caves in the Oudtshoorn vicinity. The opportunity to visit an Ostrich Farm and ride one of these feathered beauties is also available.
Further north you will pass through what was formerly known as the Transkei and encounter rural habitats and relaxed coastal villages such as Coffee Bay and Port St. Johns. The latter is a small, typical Third World town which attracts many European tourists due to its spectacular natural surroundings and relaxed, friendly atmosphere. PSJ is also the (unofficial) South African capital of "ganja" (marijuana), which probably accounts for the myriads of backpackers who pass through the region. And, of course, home to the eccentric and much publicized Ben Decker (artist/actor and ex-politician wannabee) who lives in a cave with a stunning 180 degree sea view.
Located at the mouth of the Umzimvubu River, the town combines virgin forests with stunning ocean views and is pure paradise for any nature lover who wishes to explore its many hiking trails, discover secluded waterfalls and awesome views from the top of Mount Thesiger. I've been privileged to spend a few years as a "local" (before returning to my Cape Town roots) and can highly recommend a stay at the Umzimvubu Retreat Guest House.
For those who prefer to add some bright lights to their itinerary, major cities en route such as East London, Port Elizabeth and, of course, both Durban and Cape Town offer everything you may desire. In brief, no matter whether you are seeking natural splendor, historical highlights, an adrenalin rush or sophisticated city life, the Garden Route combines it all in a breathtakingly beautiful package.